| Atlanta | ATL | San Juan | SJU | Delta | Daily |
| Atlanta | ATL | St Thomas | STT | Delta | Daily |
| Atlanta | ATL | Antigua | ANU | Delta | Saturday |
| Baltimore | BWI | San Juan | SJU | Southwest | Daily |
| Boston | BOS | San Juan | SJU | Jetblue | Mon, Tues, Wed, Thur, Fri, Sat |
| Boston | BOS | St Thomas | STT | Jetblue | Friday |
| Charlotte | CLT | San Juan | SJU | American Airlines, US Airways | Daily |
| Charlotte | CLT | St Thomas | STT | American Airlines | Daily |
| Charlotte | CLT | Antigua | ANU | US Airways | Saturday |
| Chicago | ORD | San Juan | SJU | American Airlines, US Airways, Jetblue, United | Daily |
| Dallas | DFW | San Juan | SJU | American Airlines, US Airways | Daily |
| Fort Lauderdale | FLL | San Juan | SJU | Jetblue, Spirit Airlines, Southwest | Daily |
| Fort Myers | RSW | San Juan | SJU | Sun Contry Airlines | Thurs, Sun |
| Hartford | BDL | San Juan | SJU | Jetblue | Daily |
| Houston | IAH | San Juan | SJU | United, Southwest | Daily |
| Miami | MIA | San Juan | SJU | American Airlines, US Airways | Daily |
| Miami | MIA | St Thomas | STT | American Airlines, US Airways | Daily |
| Miami | MIA | Antigua | ANU | American Airlines | Daily |
| Minneapolis | MSP | San Juan | SJU | Delta | Sat & Sun |
| New York | JFK | San Juan | SJU | American Airlines, Delta, US Airways, Jetblue, United | Daily |
| New York | JFK | St Thomas | STT | Delta, American Airlines | Mon, Thurs, Fri, Sat, Sun |
| New York | JFK | Antigua | ANU | American Airlines | Mon, Wed, Thurs, Fri, Sat, Sun |
| New York | EWR | San Juan | SJU | American Airlines, Delta, US Airways, Jetblue, United | Daily |
| New York | EWR | St Thomas | STT | United | Saturday |
| Orlando | MCO | San Juan | SJU | Jetblue, Southwest | Daily |
| Philadephia | PHL | San Juan | SJU | American Airlines, US Airways | Daily |
| Philadephia | PHL | St Thomas | STT | American Airlines, US Airways | Sunday |
| Tampa | TPA | San Juan | SJU | Jetblue, Southwest | Daily |
| Toronto, CAN | YYZ | San Juan | SJU | WestJet | Saturday |
| Washinton, D.C. | IAD | San Juan | SJU | United | Sat, Sun |
| Washinton, D.C. | DCA | San Juan | SJU | Jetblue | Daily |
| Copenhagen, Denmark | CPH | San Juan | SJU | Norwegian | Friday |
| Frankfurt, Germany | FRA | Antigua | ANU | Condor | Saturday |
| London | LGW | San Juan | SJU | Norwegian | Wed, Sat |
| London | LGW | Antigua | ANU | British Airways, Virgin Atlantic | Daily |
| Madrid, Spain | MAD | San Juan | SJU | Air Europa | Thurs, Sun |
| Oslo, Norway | OSL | San Juan | SJU | Norwegian Norwegian | Sunday |
| Stockholm, Sweden | ARN | San Juan | SJU | Avianca Aerovias | Tuesday |
| Bogotá, Columbia | BOG | San Juan | SJU | Volaris | Mon, Wed, Fri, Sat, Sun |
| Cancun, Mexico | CUN | San Juan | SJU | Volaris | Thurs, Sun |
| Mexico City, Mexico | MEX | San Juan | SJU | Copa Airlines | Thurs, Sun VIA Cancun |
| Panama City, Panama | PTY | San Juan | SJU | | Daily |
Enlarge Regions